Peter Attia· MD
But so in an ideal world, you might want a molecule that would inhibit all the substrates of mTORC1, not touch mTORC2, but then... But not do it constitutively. but also maybe not to 100 % inhibition, right?
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
But so in an ideal world, you might want a molecule that would inhibit all the substrates of mTORC1, not touch mTORC2, but then... But not do it constitutively. but also maybe not to 100 % inhibition, right?
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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catalytic inhibition means an inhibitor that's binding at the catalytic site of torque 1 and blocking phosphorylation of targets an allosteric inhibitor is a fancy way of saying an inhibitor that binds someplace else on the molecule and nonetheless inhibits it