A combination of probiotics, magnesium orotate, and a low dose of CoQ10 improved symptoms of major depression in the short term.

“There's also been at least one clinical trial study exploring how taking probiotics, and in this case, it was actually probiotics plus magnesium. It was magnesium orotate, which is just one form of magnesium, as well as, I would say, a low-ish dose of coenzyme Q10. Combining those three things in this paper entitled "Probiotics And Magnesium Orotate", it should have said "probiotics and magnesium orotate and coenzyme Q10", but the title is, "Probiotics And Magnesium Orotate" For The Treatment Of Major Depressive Disorder, A Randomized Double-Blind Controlled Trial. Now, I want to emphasize that the results of this paper show that in the short term, there's an improvement in symptoms of major depression.”