In men on TRT, progesterone may help balance disproportionately high free androgen levels, which can lead to a perpetually keyed-up sympathetic drive.

“what would be the benefits when you're on trt um what is it helping you balance out clinically I think very common we will see disproportionately High free Androgen levels in men especially when you look at a lot of guys will look at their total testosterone their free testosterone their shbg but what often goes overlooked is shbg binds DHT with I believe it's a five times higher Affinity than testosterone might be 10 I think it's five though whatever it is it's much higher and that ratio of DHT to testosterone to estrogen that's freely circulating like you're regulating mechanism in the body the primary one cuz shbg is like the main thing that determines how male you are essentially”

“I do believe and see it play out where it could be useful to balance out some of that sympathetic drive and whatnot”