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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
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Why is progesterone so important for women? | Peter Attia and Derek MPMD — Whalespan

Content›Video›Why is progesterone so impor…

Why is progesterone so important for women? | Peter Attia and Derek MPMD

Peter Attia10m · 2024-03-13

Claims Made

18

Claims Supported

9

Support Rate

50%

Support rate

9 of 18 claims supported

9 supported9 partial / not

Claims from this content

16

✓Well SupportedSex Hormone Binding Globulin (SHBG) binds androgens and estrogens, influencing free androgen availability.✓Well SupportedProgestogenic activity acts as a GABA agonist and improves sleep.✓Well SupportedSubcutaneous testosterone injections every other day can maintain stable hormone levels for TRT.✓Well SupportedFinding a woman's individual optimal dose of progesterone is key, with some tolerating 50-100mg well.◐Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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In men on TRT, progesterone may help balance disproportionately high free androgen levels, which can lead to a perpetually keyed-up sympathetic drive.

◐Partially SupportedProgesterone can exert negative feedback on the hypothalamic-pituitary-gonadal axis and may possess anti-androgenic activity.

◐Partially SupportedOral progesterone administration leads to first-pass metabolism, producing different metabolites compared to cream or injection forms.

◐Partially SupportedLong ester testosterone compounds used in TRT eliminate the pulsatile rhythm of natural hormone production.

◐Partially SupportedProgesterone metabolites like allopregnanolone may help balance androgenic signaling and reduce anxiety.

◐Partially SupportedA decrease in SHBG levels after starting TRT indicates a disproportionate regulatory mechanism is in play, which may need to be accounted for if experiencing anxiety or sleep difficulties.

◐Partially SupportedThe ratio of free DHT to testosterone to estrogen is a primary regulatory mechanism in the body, influenced by SHBG.

◐Partially SupportedA free androgen dominant environment can lead to a perpetually keyed-up sympathetic drive.

◐Partially SupportedProgesterone is a precursor in the steroidogenesis cascade, branching to androgens, adrenal hormones, glucocorticoids, and sex hormones.

◐Partially SupportedWhen on TRT, negative feedback effects of hormones like progesterone are less relevant due to hormonal suppression.

◐Partially SupportedProgesterone can lower the body's ability to have androgen-like effects.

◐Partially SupportedIndividuals on TRT may overlook the dominance of their free androgen profile, as measurements do not always include DHT or free DHT.