Progestogenic activity acts as a GABA agonist and improves sleep.

“that progesterone seems to be really protective for our sleep”

“what we found is that progestin probably through the effects of Gaba is very effective at settling your brain down and allowing for sleep so I'm having my patients take their progesterone Orly at night before they go to bed and we're seeing better sleep with that”

“So it can be impactful on quality of life because you get the downstream conversion to some of those neurosteroids that you know may be inhibited in post finansteride patients. Wow. Yeah. I never I I'd never heard of that. Um, that's super interesting. Yeah. No, not common or you know, but it's uh why would it why would it not work why would it work in women and not work in men if you had you know, like a reasonably low progesterone level you know. Yeah. Um, and you're not expected to have a sky-high progesterone anyway, but it's some of the downstream neuroststeroid metabolites that you make through five alpha reduction and whatnot that are very gabaurgic and anzolytic and can help certain people. And maybe that's useful for a specific guy who has a low SHBG and is in a state of high sympathetic drive on his test and needs to calm down or like there are certain use cases that are more individual dependent for sure and not necessarily dictated solely by let's like lab resulted out and anywhere we just look for red and then replace it.”

“I've seen progesterone use in men on TRT actually reasonably effective in sleep quality. Kind of depends on the How much progesterone? Like the same amount as women, like one to 200 milligrams. You don't have any HBTA suppression because you're shut down anyway. So it can be impactful on quality of life because you get the downstream conversion to some of those neurosteroids that you know may be inhibited in post finansteride patients.”

“if you look at a steroid Genesis Cascade which is like in layman's terms I guess if you took cholesterol and then all of the different things it could turn into when you cleave it and through enzymatic Pathways turn it into you know um glucocorticoids or like Downstream to adrenal steroids and downstream to testosterone and DHT and estradi and estrone and all that stuff like that is called steroid Genesis the synthesis of all these steroid hormones in your body”

“why do you think that is why do you think progesterone is so important for women outside of reproductive like standard utility”