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Content›Video›How to Optimize Your Hormone…

How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Andrew Huberman2h 59m · 2022-04-11

Support Rate

66%

250 of 381 claims supported

Support rate

250 of 381 claims supported

250 supported131 partial / not

Claims from this content

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✓Well SupportedInside Tracker's platform provides actionable protocols to adjust blood markers into ideal ranges for health.✓Well SupportedRegular blood work is essential for monitoring factors impacting immediate and long-term health.◐Partially SupportedIntravenous BPC-157 administration provides a rapid, short-term anti-inflammatory effect, while subcutaneous administration offers a longer-lasting effect.✕Not SupportedElevated scrotal temperature from hot tubs and saunas is detrimental to sperm quality.✕Not SupportedIndividuals with cancer or high risk of cancer should avoid BPC 157 due to its pro-angiogenic effects.

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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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✓Well Supported

Achieving 180-200 minutes of Zone 2 cardio per week has significant positive effects on longevity, cardiovascular function, metabolic fuel utilization, and musculature.

✓Well SupportedDeliberate cold exposure may be beneficial for fertility and hormone production in males.

✓Well SupportedTestosterone amplifies an individual's existing traits, such as sexual arousal, libido, aggressiveness, spontaneous aggression, and reactive aggression.

✓Well SupportedFadogia agrestis may be beneficial for individuals with low luteinizing hormone levels, provided there are no issues with prolactin or opioid receptor antagonism.

✓Well SupportedBoron supplementation can increase mean plasma free testosterone and decrease plasma estradiol, while also increasing dihydrotestosterone, cortisol, and vitamin D.

✓Well SupportedLow-dose tadalafil (2.5-5mg daily) can help with urinary symptoms and erectile function.

✓Well SupportedCreatine supplementation may increase dihydrotestosterone (DHT).

✓Well SupportedIn women, resistance training tends to balance estrogen and progesterone and promote more youthful levels of growth hormone and a better cortisol response.

✓Well SupportedThesis uses phosphatidylserine and alpha GPC in their nootropics to optimize brain and body states.

✓Well SupportedProgestogenic activity acts as a GABA agonist and improves sleep.

✓Well SupportedIndividuals with XY chromosomes and a mutated androgen receptor gene will develop as infertile females despite having the SRY gene and producing testosterone.

✓Well SupportedSex Hormone Binding Globulin (SHBG) binds androgens and estrogens, influencing free androgen availability.

✓Well SupportedChronic marijuana use (more than twice a week) significantly reduces testosterone and elevates aromatase enzymes.

✓Well SupportedAdult women, on average, have higher testosterone than estrogen levels in ng/dL, but less than adult men.

✓Well SupportedIt is advisable to discuss peptide use, including dosing regimens and duration, with a doctor to ensure individualized treatment.

✓Well SupportedA logical starting dose for TRT is 100-120 mg per week, aiming for symptom relief and reasonable total and free testosterone levels.

✓Well SupportedBeing very lean, below 10% body fat, is likely to negatively impact testosterone levels.

✓Well SupportedBPC157 is used post-injury in sports, for muscle building, by endurance athletes, and for cosmetic purposes to increase blood flow and promote tissue repair.

✓Well SupportedSix to eight Brazil nuts contain approximately 550 micrograms of selenium.

✓Well SupportedMetformin is prescribed to many PCOS patients to increase insulin sensitivity, facilitating sugar clearance from the blood into cells for energy.

◐Partially SupportedOral L-carnitine has about 10-15% bioavailability, requiring a 10x higher dose compared to injection to achieve similar outcomes.

✓Well SupportedBlack pepper extract (bioperine) is a 5-alpha reductase inhibitor that can affect liver cytochrome and contribute to turmeric supplement side effects.

◐Partially SupportedBPC 157 increases VEGF, promoting blood vessel growth, which is the opposite mechanism of anti-cancer medications like Avastin.

✓Well SupportedTongkat ali (400mg/day) may increase free testosterone levels and is associated with positive subjective and objective effects for some individuals.

◐Partially SupportedPhysiological levels of administered IGF-1 do not improve body composition, whereas locally acting IGF-1 from exercise does.

✓Well SupportedOral contraception prevents the peak in perceived attractiveness associated with the pre-ovulatory phase.

◐Partially SupportedBoron supplementation may temporarily decrease SHBG levels, but consistent intake might return SHBG to baseline.

✓Well SupportedSupplements and protocols, including injectable and orally ingested L-Carnitine, can improve sperm and egg health and motility.

✓Well SupportedIntra-workout glucose and carbohydrate intake is generally not necessary for workouts lasting less than two to three hours.

◐Partially SupportedIncreases in sex hormone binding globulin due to caffeine are generally not a significant concern at typical safe dosages (1-3 mg/kg body weight).

◐Partially SupportedThe oral bioavailability of L-carnitine is low (10-15%), necessitating significantly higher doses compared to injections to achieve similar outcomes.

✓Well SupportedThe Indonesian variety of Tongkat Ali is considered most effective for potentially reducing sex hormone-binding globulin (SHBG) and thereby freeing up testosterone.

◐Partially SupportedSubcutaneous injection of testosterone has a slightly longer active half-life compared to intramuscular injection due to slower esterase activity.

✕Not SupportedThe safety and source quality of BPC-157 are critical concerns due to lack of regulation and potential for contamination or mislabeling in compounded pharmacies.

✓Well SupportedIntermittent fasting, including 24-hour fasts, has benefits for IGF-1 levels.

✓Well SupportedCaloric restriction can be particularly helpful for hormone health, especially given the prevalence of metabolic syndrome.

✓Well SupportedBrimlanotide (PT-141) is FDA-approved for treating hypoactive sexual desire disorder in women.

✓Well SupportedGenetic differences in the androgen receptor, such as CAG repeat length, influence its binding efficiency.

✓Well SupportedSleep deprivation can be the number one diagnosis for a situation where the brain is not signaling to produce more testosterone despite low testosterone levels.

✓Well SupportedOptimizing hormone health involves consistent, moderate lifestyle interventions.

◐Partially SupportedInjectable l-carnitine has high absorption, with typical doses ranging from 500 to 2,000 milligrams.

◐Partially SupportedHealthy trans fats are found in meat, cheese, and milk from ruminants.

◐Partially SupportedTongkat Ali may decrease negative feedback inhibition of estradiol and increase testosterone by weakly acting on aromatase and potentially acting as a non-selective estrogen receptor modifier.

✓Well SupportedElevated SHBG levels can persist for at least four months after discontinuing oral contraceptives.

✓Well SupportedIn men, an increased PSA during testosterone supplementation is associated with a higher risk of prostate cancer.

◐Partially SupportedIn eugonadal men, starting TRT or self-administered steroids increases the risk of sleep apnea in a dose-dependent manner.

◐Partially SupportedTadalafil increases androgen receptor density, similar to l-carnitine.

✓Well SupportedFree testosterone, which is unbound, represents the smallest proportion of total testosterone in the body.

✓Well SupportedTestosterone and estrogen are present in all sexes and vary in degrees and ratios.

◐Partially SupportedIGF-1 has a half-life of days to a week, which is significantly longer than growth hormone's half-life of hours, allowing for sustained effects.

◐Partially SupportedThe extent to which DHEA increases testosterone or estrogen depends on the individual's baseline levels of these hormones.

◐Partially SupportedL-carnitine transports medium-chain fatty acids across the mitochondrial membrane for utilization.

◐Partially SupportedHormones impact mood and behavior, and mood and behavior can impact hormones.

◐Partially SupportedPituitary microadenomas are common and often go undiagnosed, with individuals experiencing fatigue and elevated prolactin.

◐Partially SupportedTesamorelin is a growth hormone-releasing peptide (GHRP) that is structurally similar to endogenous growth hormone-releasing hormone.

✕Not SupportedSubmerging testicles in water, such as in hot tubs or baths, is detrimental to fertility due to direct heat transfer.

✓Well SupportedApproximately 33% of weight loss from caloric restriction or fasting is lean body mass.

✕Not SupportedHigh doses of Vitamin B6 may exacerbate peripheral neuropathy in some individuals.

✕Not SupportedMelanotan may increase the risk of melanoma.

◐Partially SupportedFadogia agrestis is generally considered safe for short-term use, such as three weeks on and one week off.

✓Well SupportedThe ovaries produce estrogen, progesterone, and testosterone, and adding testosterone is crucial when estrogen and progesterone are optimized for women's health.

◐Partially SupportedhCG suppresses luteinizing hormone (LH) output in a dose-dependent manner.

◐Partially SupportedAdipose tissue can convert testosterone into estrogen, potentially causing gynecomastia in overweight individuals.

◐Partially SupportedInjecting L-carnitine subcutaneously can cause significant burning; intramuscular injection is preferred for reduced pain and better absorption.

?Limited ResearchIntermittent fasting may extend lifespan, although this is still an open question and difficult to study in humans.

◐Partially SupportedInsulin resistance is linked to PCOS and contributes to visceral fat and inflammation.

✕Not SupportedTurmeric supplementation can significantly reduce DHT levels and negatively impact feelings of vitality.

◐Partially SupportedL-carnitine shows promising data for improving egg and sperm quality and fertility in both women and men.

✓Well SupportedMagnesium and L-theanine are exceptions to the rule that sleep supplements should not be taken daily.

✓Well SupportedMarijuana and exogenous cannabinoids significantly lower sex hormones in men and women.

◐Partially SupportedHuman chorionic gonadotropin (hCG) is similar to TSH and increases significantly during the first trimester of pregnancy.

◐Partially SupportedSpreading testosterone dosages into two or three smaller administrations per week is a current trend.

◐Partially SupportedTaking hCG and selenium are considered interventions for thyroid health.

◐Partially SupportedThe negative effects of 5-alpha reductase inhibition, such as from turmeric or saw palmetto, are nearly always reversible.

◐Partially SupportedPeptides are gaining popularity partly because they are not classified as steroids, which are associated with negative side effects like acne and rage.

◐Partially SupportedSome physicians are prescribing peptides like BPC-157 off-label.

✕Not SupportedIndividuals with low DHT levels or androgen receptor insensitivity should avoid bioavailable curcuminoids and black pepper extract.

◐Partially SupportedTesamorelin is a longer-lasting growth hormone secreting peptide than sermorelin, typically taken three times per week compared to five times per week.

◐Partially SupportedGABA supplementation for sleep enhancement should be taken no more than three to four nights per week.

◐Partially SupportedOptimizing sleep is important for hormone and mitochondrial health.

◐Partially SupportedSunlight exposure, encompassing outdoor activities, cold exposure, and heat exposure, is a key component of health optimization.

✓Well SupportedIndividuals should have baseline blood tests of hormone levels and metabolic markers in their 20s, 30s, and 40s to track changes.

◐Partially SupportedMen tend to get prostate cancer when their testosterone levels are lowest, not highest.

◐Partially SupportedEstrogen upregulates the PRL gene, which directly increases prolactin synthesis.

◐Partially SupportedSleep supplements containing GABA should not be taken daily, similar to alcohol and other potent GABA agonists.

◐Partially SupportedOpiate agonists, GABA agonists, and smoked marijuana can decrease LH and FSH, subsequently reducing testosterone.

◐Partially SupportedTaking 600 milligrams of garlic capsules containing allicin can significantly reduce TMAO levels.

◐Partially SupportedTMAO production may not be a significant issue in general, and people should not limit choline and carnitine.

✕Not SupportedHigh doses of l-carnitine or choline can convert to TMAO, a potential carcinogen, especially with a dysregulated gut microbiome.

◐Partially SupportedL-carnitine supports mitochondrial function for chromosome separation during egg maturation and sperm motility.

✕Not SupportedMedications like finasteride and Propecia can dramatically reduce DHT and lead to sexual and mood side effects.

◐Partially SupportedMenstrual cycles can align when women spend a lot of time together due to pheromonal and hormonal cross-talk, including prolactin.

◐Partially SupportedDietary approaches should be individualized for optimal performance.

◐Partially SupportedEating dinner within two to three hours before sleep allows for good growth hormone output, though longer fasting periods yield slightly more.

◐Partially SupportedFinasteride inhibits 5-alpha reductase isoenzymes 2 and 3, saw palmetto inhibits 1 and 2, and dutasteride inhibits all three.

◐Partially SupportedA systemic decrease in DHT may benefit individuals with prostate issues or myocardial hypertrophy.

◐Partially SupportedDeclining energy, focus, and athletic performance from the 20s to age 50 can indicate a need for hormone lab workup.

◐Partially SupportedKey initial health inquiries include blood pressure, mental health, family history, and hormone health.

◐Partially SupportedHCG can be used as an alternative to testosterone therapy for maintaining fertility and testicular size.

◐Partially SupportedProgesterone-only birth control pills like Slynd are anti-androgenic and can be used for PCOS patients who do not require contraception but need symptom management.

◐Partially SupportedDiet, exercise, caloric restriction, stress management, sleep, and sunlight are critical for optimizing hormone health at all ages.

◐Partially SupportedPeople 500 years ago were more sensitive to androgens, suggesting potentially more significant hair loss then compared to now.

◐Partially SupportedHigh doses of nicotine over long periods have a dose-dependent effect on hormone profiles.

◐Partially SupportedImproving or optimizing hormones is a critical aspect of mental health, physical health, and performance.

◐Partially SupportedDHT, testosterone, and DHEA bind to the androgen receptor, mediating their effects in both men and women.

◐Partially SupportedThe androgen receptor gene is located on the X chromosome, meaning men inherit it from their mother.

◐Partially SupportedLight to moderate alcohol consumption is associated with decreased brain volume, but this may not necessarily translate to diminished cognitive function.

◐Partially SupportedTurkesterone and Beta-Ecdysterone activate the beta estradiol receptor.

◐Partially SupportedVaricocele negatively impacts sperm production by raising testicular temperature due to impaired venous blood flow.

◐Partially SupportedIncreasing free testosterone from Tongkat Ali is primarily related to psychological effects rather than muscle growth.

◐Partially SupportedhCG may help restore hormone health after finasteride by upregulating 5-alpha reductase enzymes.

◐Partially SupportedThe ratio of estrogen and testosterone influences feelings of well-being, optimism, anxiety, reproduction, and sexual behavior.

◐Partially SupportedProlactin inhibits the release of testosterone from the pituitary gland.

◐Partially SupportedDuring pregnancy, free T4 levels, not TSH, are used to guide thyroid medication dosage.

◐Partially SupportedOral contraceptives can alter daily peaks and troughs in libido and attractiveness without fundamentally changing personality.

◐Partially SupportedOpiate agonists decrease LH and FSH, leading to reduced testosterone, similar to smoked marijuana.

◐Partially SupportedInjecting L-carnitine into a specific muscle is likely to increase androgen receptor density in that muscle.

◐Partially SupportedHigh SHBG levels can lead to higher total DHT by reducing its metabolism, but may result in less free DHT.

◐Partially SupportedCreatine monohydrate can significantly increase the conversion of testosterone to DHT and may also serve as a brain fuel and cognitive enhancer.

◐Partially SupportedDiscontinuing creatine supplementation should lead to hair regrowth if hair loss is suspected to be caused by creatine.

✕Not SupportedLow-dose tadalafil can lower blood pressure and theoretically increase the risk of vasovagal syncope.

✓Well SupportedHigh prolactin and low dopamine levels after breastfeeding can make subsequent sexual activity difficult.

◐Partially SupportedThe upper limit for normal testosterone levels in the US is 900 ng/dL, while in some other countries it is 1200 ng/dL.

◐Partially SupportedP5P (pyridoxine-5-pyrophosphate), the active form of vitamin B6, is a safer alternative to standard pyridoxine due to its pre-activated nature and lack of buildup.

◐Partially SupportedAromatase gene activity can vary and contribute to pubertal gynecomastia.

◐Partially SupportedThe primary purpose of exercise and caloric restriction, including intermittent fasting, is to increase healthspan, not solely to change scale weight.

◐Partially SupportedInsulin should be prescribed by a doctor to avoid incorrect dosing that can be fatal.

◐Partially SupportedIntermittent fasting with 8-12 hour eating windows is not detrimental to hormone health for healthy, lean individuals.

◐Partially SupportedDiagnosis of PCOS involves assessing androgen excess and/or insulin resistance, with polycystic ovaries not strictly required if androgen excess is present.

◐Partially SupportedSpiritual health, mental health, and physical health are interconnected, and the absence of one negatively impacts the others.

◐Partially SupportedAntidepressants like Wellbutrin, stimulants like cocaine, and ADHD medications like Adderall and Vyvanse increase dopamine levels.

◐Partially SupportedDuring periods of high prolactin, low dopamine, and low testosterone (e.g., pregnancy, breastfeeding), planning for good times is important.

◐Partially SupportedTMAO levels can be measured in a blood test.

◐Partially SupportedViagra (sildenafil) may increase eyebrow hair growth and potentially help prevent androgenetic alopecia by promoting vasodilation and improving scalp blood flow.

◐Partially SupportedGHRPs have been studied for use in head injuries.

◐Partially SupportedTamsulosin (Flomax) is an alpha antagonist used to support prostate and urinary system health.

✕Not SupportedGrowth hormone-releasing peptides are generally not needed unless diagnosed with lipodystrophy or growth hormone deficiency.

✕Not SupportedA risk for women taking hCG is that it will make any pregnancy test positive.

◐Partially SupportedFor pathology prevention in women, such as breast cancer and osteoporosis, estrogen and progesterone levels are more critical to monitor than testosterone.

◐Partially SupportedCalcium D-glucarate, taken at 500-1000 mg, can aid estrogen control by assisting with excretion and receptor sensitivity without significantly lowering estrogen levels.

◐Partially SupportedReduced gastric protective compounds, possibly due to aging and atrophic gastritis, can increase colitis and diverticulitis incidence.

◐Partially SupportedProstate cancer is highly prevalent in older men, with at least 50% chance in 80-year-olds and 90% chance in 90-100 year-olds.

◐Partially SupportedDIM can reduce both estrogen and testosterone levels.

◐Partially SupportedThe hair cycle includes antigen, catagen, and telogen phases, followed by hair loss and regrowth from the stem cell niche.

◐Partially SupportedHairs shed due to telogen effluvium may not return if a year passes without regrowth.

◐Partially SupportedLong-term oral contraceptive use is unlikely to significantly accelerate age-related fertility decline compared to factors like resistance training and caloric intake.

◐Partially SupportedSymptoms of androgen excess in women, indicative of PCOS, include androgenic/hormonal acne, hirsutism, deepening of the voice, and male pattern baldness.

◐Partially SupportedGenetic polymorphisms can influence carbohydrate and sugar metabolism.

◐Partially SupportedVitamin E, particularly mixed tocopherols with adequate gamma-tocopherol, may help manage elevated prolactin.

◐Partially SupportedEating garlic is a viable alternative to taking garlic supplements for cardiovascular benefits.

◐Partially SupportedEliminating casein or gluten may help reduce prolactin levels.

◐Partially SupportedHuman chorionic gonadotropin (hCG) can upregulate aromatase.

◐Partially SupportedTongkat ali likely does not require cycling off due to its effects on aromatase and estrogen receptor modification.

◐Partially SupportedCold exposure in women can increase beta-adrenergic receptor activity in the central nervous system and astrocytes, potentially decreasing appetite.

◐Partially SupportedOptimizing hormone health involves six pillars: diet, exercise, stress optimization, sleep optimization, sunlight exposure, and nicotine cessation.

◐Partially SupportedStress optimization is important for achieving optimal health.

◐Partially SupportedIntegrating spiritual, mental, and physical health is foundational for overall health and longevity.

◐Partially SupportedBremelanotide is FDA-approved for lipodystrophy and a rare genetic condition involving hypopigmentation and morbid obesity.

◐Partially SupportedBlood tests for advanced testing are becoming more affordable through options like FSAs, HSAs, or Care Credit.

◐Partially SupportedSHBG binds androstenedione, DHEA, and estradiol with progressively weaker affinity.

◐Partially SupportedElevated high-sensitivity C-reactive protein (hs-CRP) is a general marker of inflammation associated with increased reactive oxygen species, which can cause mutations and atypical cell turnover in the prostate.

◐Partially SupportedIt is advisable to establish a baseline hs-CRP level when not experiencing acute conditions and to aim for a very low CRP.

◐Partially SupportedAn overactive sympathetic nervous system impairs rest and sleep quality.

◐Partially SupportedSleep optimization is crucial for mitochondrial health.

✕Not SupportedViagra can potentially alter the function of the eye's rays and cones, leading to a recommendation against its use for pilots.

◐Partially SupportedIn premenopausal women, testosterone can be produced by the theca cells in the ovaries.

◐Partially SupportedTadalafil acts as a weak androgen receptor sensitizer, potentially increasing the density of available androgen receptors for binding.

◐Partially SupportedA shedding of hair after starting 5-alpha reductase inhibitors is a normal process where unhealthy hairs are jettisoned, allowing for the creation of a healthier new follicle.

◐Partially SupportedFinasteride is a hormonal medication used to decrease prostate enlargement in Benign Prostatic Hyperplasia.

◐Partially SupportedPost-finasteride syndrome is a real condition combining organic and inorganic disease, similar to fibromyalgia.

◐Partially SupportedIn individuals with PCOS, the more sensitive androgen receptor gene is typically active, while the other is methylated and inactive.

◐Partially SupportedDHT and THP are active in the central nervous system and can influence mood, motivation, and feelings of well-being by binding to androgen receptors.

◐Partially SupportedA common dose of hCG for fertility treatment is 10,000 IUs, which can be administered via autoinjector pins that may not allow dosing below 5,000 units.

◐Partially SupportedThe 'cat string' phenomenon, an intermittent engagement mechanism, may apply to relationship attachment.

◐Partially SupportedGhrelin-like peptides may be used for growth hormone deficiencies in the future.

◐Partially SupportedTaking exogenous testosterone to achieve a testosterone level of 900-1000 ng/dL is sometimes referred to as 'sports TRT'.

◐Partially SupportedIncreased hCG during pregnancy can prevent hypothyroidism or hypothyroxinemia, a common cause of miscarriage.

◐Partially SupportedPolycystic Ovarian Syndrome (PCOS) has a prevalence potentially as high as 10-20% of women.

◐Partially SupportedThe protective effect of moderate alcohol intake, particularly red wine with polyphenols, may outweigh its deleterious effects.

◐Partially SupportedAndrew Huberman took 600mg of Fadogia agrestis daily for an extended period without experiencing negative side effects or signs of testicular toxicity, based on blood work.

◐Partially SupportedDopamine agonists like P5P (pyridoxine-5-pyrophosphate) can help manage elevated prolactin.

◐Partially SupportedIt is important to consult a physician and perform blood work before taking supplements to avoid flying blind.

◐Partially SupportedA reasonable cycling protocol for tongkat ali is 11 months on and 1 month off.

◐Partially SupportedInterventions can decrease prostate turnover, inflammation, and congestion, and prostate MRIs offer structural and functional assessment beyond PSA.

◐Partially SupportedMaintaining prostate health is best approached by identifying and avoiding detrimental factors.

◐Partially SupportedMaintaining adequate blood flow to the pelvic region is key for health.

◐Partially SupportedAllicin in garlic may have positive effects on cardiovascular tone and blood flow.

✕Not SupportedGinkgo biloba can cause headaches and is therefore avoided in nootropics and supplements.

✕Not SupportedFadogia agrestis is not recommended for long-term continuous use due to insufficient safety evidence.

◐Partially SupportedA PSA level of 4 or less is an indicator of excessive prostate growth, with levels above this suggesting potential issues.

◐Partially SupportedHuman placental lactogen is the cause of sugar spikes in gestational diabetes, with higher placental tissue leading to exponentially higher risk.

◐Partially SupportedA potential testosterone augmentation protocol involves cycling 600mg of Fadogia and 400mg of Indonesian tongkat ali for three weeks on and one week off.

◐Partially SupportedHigh intake of plant polyphenols can inhibit the enzyme that converts testosterone to DHT.

◐Partially SupportedSome XX individuals naturally produce high testosterone levels from theca cells, leading to exclusion from certain Olympic distances.

◐Partially SupportedNaltrexone may help antagonize prolactin and opioid receptors to increase LH, particularly in individuals recovering from opiates or alcohol.

◐Partially SupportedD-chiro-inositol may be a preferable alternative to oral contraceptives or spironolactone for women with PCOS seeking to reduce androgen activity.

◐Partially SupportedAwareness of potential hormonal side effects can reduce their severity and frequency when they occur.

◐Partially SupportedDopamine agonists like cabergoline can decrease prolactin-producing cells, including pituitary microadenomas.

◐Partially SupportedTaking time apart from a partner can restore excitement in the relationship upon reunion.

◐Partially SupportedA prolactin level under 40 is generally not a significant concern unless visual or olfactory symptoms are present.

◐Partially SupportedDIM is a weak antiestrogen and antiandrogen that women with PCOS should consider.

◐Partially SupportedUseful dosages for boron supplementation range from 3 to 6 milligrams, taken once to twice daily.

◐Partially SupportedInterventions that alter aromatase can support a healthy testosterone to estrogen ratio.

◐Partially SupportedInjecting hCG can theoretically be used to fake a pregnancy test.

◐Partially SupportedBoth high caloric intake and high fat intake can increase aromatase.

◐Partially SupportedStrategies to upregulate 5-alpha reductase enzymes after stopping finasteride or hCG include waiting, tadalafil, creatine, or hCG.

◐Partially SupportedAchieving optimal health is more effective when pursued as a household unit.

◐Partially SupportedProlactin aids in nesting instincts, breastfeeding, and lung maturity in infants by influencing the sphingomyelin to lecithin ratio.

◐Partially SupportedIndividuals sensitive to estrogen should limit alcohol intake to no more than two glasses three times a week.

◐Partially SupportedAlcohol consumption significantly increases aromatase activity.

◐Partially SupportedHigh alcohol intake decreases testosterone levels.

◐Partially SupportedSunlight exposure is a key component for optimizing hormone health.

◐Partially SupportedThe University of Kansas medical school emphasizes full-spectrum care, including exercise as medicine and food as medicine.

◐Partially SupportedContinuous use of tongkat ali for years without cycling is supported by normal liver enzymes and no adverse effects.

◐Partially SupportedCaloric restriction by 40% in obese mice improves testosterone parameters, similar to obese humans.

◐Partially SupportedPlanning for positive experiences during anticipated relationship crises can help mitigate their impact.

◐Partially SupportedVitamin B6 may shorten the refractory period after orgasm by blunting the prolactin response.

◐Partially SupportedThe optimal dosage for many interventions is zero, and substances should not be used for longer than a week if not necessary.

◐Partially SupportedSaw palmetto or curcumin may be considered as anti-androgens for individuals with a genetic predisposition to enlarged prostates or fast-growing prostate cancers.

◐Partially SupportedIndonesian tongkat ali is a preferred source.

◐Partially SupportedProstatitis and infections are common causes of prostate issues in younger males.

◐Partially SupportedInsulin was discovered to cure diabetes in animals and subsequently saved the lives of type one diabetics.

◐Partially SupportedBenign prostate hyperplasia (BPH) is characterized by non-cancerous prostate growth, which can lead to urinary and sexual difficulties.

◐Partially SupportedIncreased Zone 2 cardiovascular exercise may reduce the importance of long-duration caloric restriction for health benefits.

◐Partially SupportedHair shedding when starting 5-alpha reductase inhibitors or minoxidil may indicate healthy follicle regeneration.

◐Partially SupportedA typical recommended dose of L-carnitine for fertility and androgen receptor upregulation is 1 gram per day.

?Limited ResearchIce baths may increase testosterone levels.

◐Partially SupportedGrowth hormone-producing microadenomas are the second most common type and can cause acromegaly or gigantism.

◐Partially SupportedGHK-copper peptide, produced endogenously at younger ages, aids liver regeneration and can significantly help the nervous system, especially in individuals with copper deficiency.

◐Partially SupportedExcitement and attraction in new romantic relationships are largely regulated by the dopaminergic system, which changes over time.

◐Partially SupportedTestosterone undecanoate in a special lymphatic absorption capsule (JATENZO) is FDA-approved and taken twice daily, offering steady half-lives.

◐Partially SupportedGrowth hormone primarily acts on the liver to stimulate IGF-1 production.

✕Not SupportedGrowth hormone-releasing hormone peptides like sermorelin carry risks including tumor growth and cancer.

◐Partially SupportedTesamorelin is an FDA-approved peptide used to treat lipodystrophy by redistributing body fat.

✕Not SupportedFadogia agrestis is not recommended for individuals with already high luteinizing hormone (LH) levels.

◐Partially SupportedInsulin is a safe and life-saving peptide when prescribed correctly.

✕Not SupportedBenefits of growth hormone peptides like lipolysis and increased lean body mass can often be achieved through other means, and cosmetic benefits can be obtained with topicals.

◐Partially SupportedHypoestrogenism is linked to an increased presence of atypical cells in the prostate.

✕Not SupportedSome clinics promote hCG as a non-suppressive alternative to TRT, despite it being suppressive of LH.

✕Not SupportedInhibiting estrogen with aromatase inhibitors can disrupt brain function, cause connective tissue issues, and reduce libido.

✕Not SupportedLifestyle interventions are often sufficient for estrogen control in most individuals.

◐Partially SupportedDiet and exercise are the two most powerful factors for health optimization.

◐Partially SupportedPreventative medicine, including mindfulness and programs like 'Walk with a Doc', is an important aspect of health that has been historically underemphasized.

◐Partially SupportedTestosterone replacement therapy can be administered via injections (using esters like cypionate, enanthate, decanoate, undecanoate) or topical application, with injections often preferred due to variability and absorption issues with topicals, especially for individuals with low SHBG.

◐Partially SupportedOral contraception use for 6 to 12 months may temporarily impact fertility, but fertility is generally expected to return to baseline levels within 6 to 12 months after discontinuation.

◐Partially SupportedhCG can significantly increase estrogen levels.

◐Partially SupportedTelogen effluvium can occur after pregnancy or with thyroid pathologies.

◐Partially SupportedHair loss and regrowth is a natural and continuous process, analogous to sharks regrowing teeth.

◐Partially SupportedProstate cancer incidence increases significantly with age.

◐Partially SupportedProstate cancer is arguably a normal process with aging, while rapid aging is abnormal.

◐Partially SupportedReduced progestogenic activity during menopause contributes to poorer sleep quality in women.

◐Partially SupportedVegans may be at risk of insufficient healthy fats or nutrients for a healthy testosterone to estrogen ratio.

◐Partially SupportedA diet rich in prebiotic and probiotic fiber can help prevent diverticulitis, colitis, and prostate infections.

◐Partially SupportedTaking exogenous testosterone to achieve high-end levels (900-1000 ng/dL) is sometimes referred to as 'sports TRT'.

◐Partially SupportedDetermining individual carbohydrate tolerance can be done through biofeedback or genetic testing interpreted by a qualified physician.

◐Partially SupportedCaloric restriction, intermittent fasting, and exercise all contribute to weight loss through the principle of calories in, calories out.

◐Partially SupportedLow prolactin levels during pregnancy can lead to an increased risk of respiratory distress in newborns.

◐Partially SupportedExogenous growth hormone administration, unlike naturally elevated levels from saunas or intermittent fasting, has been associated with cancers.

◐Partially SupportedPituitary microadenomas, PCOS, and pre-diabetes are common conditions with high prevalence.

◐Partially SupportedInjectable testosterone esters require longer ester chains when SHBG is lower to achieve a desired effect.

✕Not SupportedTaking a turmeric supplement containing curcumin caused the speaker to feel unwell with decreased energy and vitality.

◐Partially SupportedDIM acts as an anti-estrogen and anti-androgen and may indicate excessive TRT dosage.

◐Partially SupportedDutasteride mesotherapy, involving localized injections in areas prone to male pattern baldness, is a promising topical treatment that acts locally to decrease testosterone to DHT conversion in the scalp, potentially avoiding systemic side effects.

◐Partially SupportedHaving female offspring is associated with a slightly increased likelihood of developing prostate cancer, potentially linked to estrogen's role.

◐Partially SupportedModified testosterone metabolites can cross the blood-brain barrier and act as GABA agonists.

◐Partially SupportedCrashing estrogen levels can paradoxically lead to reduced libido.

◐Partially SupportedHigh-fat meals can upregulate aromatase, which may be a concern for individuals on a ketogenic diet with hyperestrogenism.

◐Partially SupportedGrowth agonists like thymosin beta-4 are synergistic with GHK-copper peptide and may contribute to better healing in children.

◐Partially SupportedMany individuals with testosterone levels between 300-900 ng/dL opt for testosterone replacement therapy even without overt hypogonadism.

◐Partially SupportedThe American Heart Association recommends an average of one to two alcoholic drinks per day for men and zero to one drink per day for women.

◐Partially SupportedTrue growth hormone deficiency can negatively impact sleep quality, which can be improved with hormone replacement therapy.

◐Partially SupportedMyo-inositol is an insulin sensitizer, while D-chiro-inositol is a weak antiandrogen, and the specific type matters for males and females.

◐Partially SupportedOligomenorrhea, defined as menstrual cycles longer than 35 days or fewer than nine per year, is a common sign of PCOS, often resulting from androgen dominance.

◐Partially SupportedSynthetic progestins in oral contraceptives can influence platelet count and SHBG levels, potentially increasing blood clot risk.

◐Partially SupportedOral contraceptives containing synthetic estrogen like ethanol estradiol can blunt the natural increase in testosterone and DHT that occurs before ovulation in women.

◐Partially SupportedInfertility is a common presenting complaint for women with PCOS.

◐Partially SupportedBoth men and women experience a prolactin increase when expecting a child.

◐Partially SupportedHair loss due to DHT is dependent on individual sensitivity of the androgen receptor and gene transcription that causes follicle cell death.

◐Partially SupportedInsulin resistance in the context of PCOS can be indicated by obesity, pre-diabetes, a HOMA-IR over two, or a fasting insulin over six.

◐Partially SupportedDHT activates the androgen receptor gene, contributing to feelings of well-being and motivation, and is active in the central nervous system.

◐Partially SupportedLH and/or hCG may improve genital sensitivity in men and women by acting as agonists in the prostate and genital tissue.

◐Partially SupportedA more functional androgen receptor increases the likelihood of developing male pattern baldness.

◐Partially SupportedExperiencing a partner through major life stages including moving in together, raising a baby, and navigating holidays is required for a full understanding of compatibility.

◐Partially SupportedSpirituality, conceptualized as the health of the body, mind, and soul, is essential for overall health and can physiologically impact well-being.

◐Partially SupportedIn the first month or two of TRT, men may enter a hypersympathetic state due to overactive androgen receptors, which can cause sleep issues.

◐Partially SupportedRegular blood testing every three to six months is recommended for preventative purposes.

◐Partially SupportedBlood testing should consider both fasting and non-fasting states for comprehensive health assessment.

◐Partially SupportedProstate cumulative damage can result from testosterone, estrogen, and growth hormone, and obesity is linked to higher prostate cancer incidence due to impaired immune system cell checkpoints.

◐Partially SupportedElevated growth hormone and IGF-1 from saunas or intermittent fasting are unlikely to cause cancer.

◐Partially SupportedFor hypogonadal patients on TRT, steady state testosterone levels are preferable to avoid side effects from peaks and troughs.

◐Partially SupportedVitamin B6 can be neurotoxic at high doses, while P5P is a safer, pre-activated form.

◐Partially SupportedOptimizing body composition and reducing body fat can help treat metabolic syndrome and potentially avoid or manage PCOS in individuals with significant insulin resistance.

✕Not SupportedMild fever or tingling after peptide injection may be due to LPS contamination, not efficacy.

◐Partially SupportedGrass-fed foods, including butter, are a source of naturally occurring trans fats, which are healthy trans fats.

◐Partially SupportedTongkat ali may help women coming off birth control pills by lowering SHBG and preventing hypoestrogenism.

◐Partially SupportedNon-romantic affiliative bonds can act as a reservoir for replenishing dopamine.

✕Not SupportedBremelanotide (PT-141) is contraindicated in individuals with a family history of melanoma or undiagnosed melanoma.

◐Partially SupportedPelvic floor exercises can be beneficial for strengthening pelvic floor muscles and ensuring proper function.

◐Partially SupportedDecreasing androgen receptor activity is recommended for androgenetic alopecia in both males and females.

◐Partially SupportedTestosterone undecanoate in a capsule form is FDA-approved and taken twice daily.

◐Partially SupportedTurkesterone or ecdysterone may cause water retention but are unlikely to reduce libido or close growth plates in bone because they do not activate the alpha-estradiol receptor.

◐Partially SupportedIndividuals should aim to consume as few highly processed and highly palatable foods as possible.

◐Partially SupportedIngesting saturated fat could theoretically be too low and disrupt the testosterone to estrogen ratio, but this is unlikely in developed countries.

◐Partially SupportedHigh luteinizing hormone (LH) may indicate gonadal issues such as heat damage to the testes, varicocele, or a history of testicular cancer.

◐Partially SupportedPCOS is not always clinically penetrant, meaning many individuals are unaware they have it until they experience infertility or subfertility.

◐Partially SupportedD-chiro-inositol is typically included in supplements in a ratio of 1:25 or 1:40 compared to myo-inositol to help induce ovulation.

◐Partially SupportedIndividuals at risk of cancer or with autoimmune diseases may benefit from lower-carbohydrate diets.

◐Partially SupportedPCOS exists on a spectrum with varying degrees of severity.

◐Partially SupportedStopping turmeric supplementation led to a recovery in energy and vitality within three to four days.

How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett — Whalespan