Andrew Huberman· PhD
When you have an increased estrogen, like estradiol, that's going to work on your pituitary to make less hormones that cause release of testosterone. So you're going to have less LH and less FSH.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
When you have an increased estrogen, like estradiol, that's going to work on your pituitary to make less hormones that cause release of testosterone. So you're going to have less LH and less FSH.
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So it's almost kind of like opiates are well known to, opiate agonists, they're going to decrease LH and FSH and subsequently testosterone.