Andrew Huberman· PhD
Cannabinoids itself, whether it's THC or CBD, are not going to reduce testosterone by themself.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Cannabinoids itself, whether it's THC or CBD, are not going to reduce testosterone by themself.
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THC in particular, not CBD, but THC in particular, is known to be strongly inhibitory for something called gonadotropin-releasing hormone. This is a hormone that's released from the brain, from the hypothalamus that then feeds onto, or I should say signals to the pituitary gland... and reduced levels of gonadotropin-releasing hormone caused by cannabis use, reduced levels of LH luteinizing hormone and FSH, which reduce levels of testosterone and sperm production in males and egg health and ovulation and menstrual function in females.
There is also significant evidence marijuana and exogenous cannabinoids lower sex hormones in men and women. (PMID: 26277482)