Fadogia agrestis may be beneficial for individuals with low luteinizing hormone levels, provided there are no issues with prolactin or opioid receptor antagonism.

“Fadogia agrestis is actually an herb that increases the levels of what's called "luteinizing hormone." Luteinizing hormone is a hormone that's released from the hypothalamus within the brain that travels to the gonads, either the ovaries or the testes, to stimulate the release of estrogen or testosterone. And Fadogia agrestis has been shown, albeit in a limited number of studies, to increase levels of luteinizing hormone and thereby levels of testosterone and estrogen in ways that some people find beneficial.”

“Fadogia was attractive to me as a supplement, because I saw increases in LH, testosterone, and free testosterone. My estrogen stayed in check, but I also did not see a down-regulation of LH when I would cycle off.”

“So you're looking for a subclinical secondary hypogonadism, which is essentially, just think of that as low LH. So in people with that lower LH and their estrogen is fine and their prolactin is fine, then Fadogia is a particularly good option.”

“However, if your LH is low, then obviously try to find out is it low? Is it deficient or is it just a little bit low? If it's low and you don't have an issue with prolactin, you don't have an issue with opioid receptor antagonism, and naltrexone can actually potentially help antagonize that to increase LH as well, especially in people recovering from opiates or likely even alcohol. So you're looking for a subclinical secondary hypogonadism, which is essentially, just think of that as low LH.”

“Fadogia agrestis has just reached a point where we have enough evidence till we know it probably helps both with luteinizing hormone release, which stimulates Leydig cells in the testes to produce more testosterone. And probably with LH receptor sensitivity as well, which is a good combination of the two.”

“Fadogia is interesting because-- it's a genus of plants. Fadogia agrestis is one of them. There's many others that are very interesting. That species is likely the most well-studied, and it will increase LH, so I would not consider it an LH mimetic, so it doesn't really mimetic. But it increases the release of luteinizing hormone from the pituitary.”

“Oh boy, here comes all the herbals." Now keep in mind that there are some herbal compounds that have pretty robust biological effects. And we talked before in our optimizing testosterone episodes about things like Tongkat Ali and Fadogia agrestis, which taken incorrect dosages and in the correct way, can be pretty potent for increasing luteinizing hormone and free testosterone that can have huge effects.”

“one of the more well documented ones is fogia agrestis that's f a o g i a separate word a g r s t i s which at least according to the literature uh that I was able to find can increase levels of lutenizing hormone and thereby levels of testosterone or levels of estrogen”