Oral progesterone administration leads to first-pass metabolism, producing different metabolites compared to cream or injection forms.

“taking it orally also is like impactful on the way it's metabolized out to get some of these proportional metabolites too because if you had it in a cream or an injection not only maybe is it harder to get the dose you want out of it but the metabolite content that you get is totally different when you have a first pass metabolism versus you skip it”

“taking it orally also is like impactful on the way it's metabolized out to get some of these proportional metabol too cuz if you had it in a cream or an injection not only maybe is it harder to get the dose you want out of it but the metabolic content that you get is totally different when you have a first past metabolism versus you skip it”