Endometriosis patients should receive progesterone with estrogen in HRT after hysterectomy to prevent stimulation of residual implants. — Whalespan
Endometriosis patients should receive progesterone with estrogen in HRT after hysterectomy to prevent stimulation of residual implants.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“However, you come and give these women estrogen, what happens? You can stimulate these endometriosis implants all over again. And this is what happens. So, endometriosis patients in general have a slightly higher increased risk of ovarian cancer, especially the ones with endometrias or advanced disease. Post-menopause hormone replacement, the estrogen, can still stimulate these implants.”
“In patients with endometriosis, even when they undergo a hyerectomy and they're using estrogen patches, you always want to give them the progesterone because otherwise you stimulate this these implants again because of unopposed estrogen.”