For a subset of women, progesterone can negatively impact mood, leading to depression or severe irritability. — Whalespan
For a subset of women, progesterone can negatively impact mood, leading to depression or severe irritability.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
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High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“it's I would say in our population it's it's about 10 to 20% for whom if you bring progesterone in the room, something goes wrong. Mhm. their mood really changes. Now, it can in some cases become depressive, but more commonly what they tell me is, and I'm quoting them, this is not me saying it, I become a raging And I'm worried I might kill my husband.”