Paul Saladino· MD
there's a paper that I was reading this morning called a review of issues of dietary protein intake in humans from 2006 and it suggests they give a tight a table in there for the upper limit of protein consumption based on kilograms and based on the mean urea excretion rate the mean rate of urea synthesis excuse me and so you know for someone like myself I'm about close to 80 kilograms the upper limit of of protein can and for me is quite high but not as high as 600 according to this chart that they're giving in the table which is again just one source the upper limit for me is between 285 and 325 grams of protein now the reason there's a variable there is based on a polymorphism or a series of polymorphisms in the urea cycle this may get too granular for people in but if they are interested they might find interesting there are a number of enzymes in the urea cycle that we use to process ammonia or specifically that we used to make nitrogen groups into urea and I know that I personally have a polymorphism in ornithine transcarbamylase it's an enzyme called OTC and when we have a polymorphism that we are not as efficient at fixing protein into fixing nitrogenous bases into urea and so my personal and upper-end of protein is probably lower than someone that doesn't have that polymorphism