We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
If you're prone, if you think you have a proclivity for schizophrenia or bipolar disorder, this is almost certainly not for you. And anyone doing the studies at Johns Hopkins for the therapeutic effects of any of these drugs, they're there ruling out people with-- first degree relatives with any of these clinical conditions.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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In particular, people who have existing or have a predisposition to psychotic episodes or bipolar episodes, even having a first relative who has bipolar, or schizophrenic, or schizotypal issues can be a rule out condition, that is can get someone eliminated from a clinical study on psilocybin for fear of triggering psychotic episodes, not just during the psilocybin journey, but potentially in a long standing way.
And then perhaps most importantly, there's a section on contraindications where it points out that of course, women who are pregnant or breastfeeding, people who have a predisposition to psychosis, those people should really avoid the use of psilocybin and other psychedelics entirely.
including the fact that people who have a predisposition or who have psychosis, or bipolar disorder, or a relative that has psychosis, or bipolar disorder.
And, again, when we say safe we're referring to people who are not prone to psychotic episodes, that don't even have a first relative that's prone to psychotic episodes.
but I do think that one has to be careful and there are certain people in populations like people who — suffer from certain types of manic bipolar or schizophrenia that really need to avoid these things kids I mean being a kid is basically being in a psychedelic State
But I am going to put a flag in the ground for trying to encourage curiosity and limit cynicism, especially for the next generation.
I will say uh I do think there are cert certain people with predisposition to psychosis that should be cautious about psychedelics.
I will say uh I do think there are cert certain people with predisposition to psychosis that should be cautious about psychedelics.
So that's the warning and and certainly populations that shouldn't go near them. people with predisposition to psychosis or mania. That's very very clear.
That's very very clear. With all of that said, the data are pretty exciting. Uh people's ability to access um an understanding of patterns in their unconscious mind
And then there's the potential risk of vulnerable populations, people who may already have pre-existing vulnerabilities to psychotic disorder or to...they might have personality disorders or some other mood...pre-existing disposition toward mood disorders that may make them unusually sensitive to potential negative effects of psilocybin.