Mouse studies investigating psilocybin's effects on brain plasticity often use dosages equivalent to double or triple the typical human therapeutic dose (e.g., 1 mg/kg).

“I should also mention that the mouse studies tended to use quite high doses of psilocybin. I wasn't shocked, but I was somewhat wide eyed for a moment to realize that most of the studies looking at changes in plasticity in the mouse brain in response to psilocybin use the equivalent of 1 milligrams per kilogram of body weight, which is if you do the math, and you translate what we were talking about before in terms of dosages, I'll just spare you all the time, it's about double, the sorts of dosages that are typically used in humans. Maybe even triple in some cases.”