Bryan Johnson· Author
Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
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Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
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Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.
Left: Magic Mushrooms (25mg psilocybin) Acute cortisol spike, deviating from the expected rhythm. An expected, healthy, time-locked stress response. It resolved quickly, returning to baseline. This is adaptive.✅
Psilocybin calmed my body and mind. Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.
Morning cortisol dropped by 42%. Systemic inflammation markedly reduced, as measured using hsCRP (undetectable 5-days post-dose). Continuous Glucose Monitoring (CGM) showed a sustained 8% decrease in my blood glucose, and 11% tighter blood glucose control and stabilization (reduced peaks and fluctuations).
My cortisol spiked to 3x morning spike levels four hours after taking the mushroom dose. Levels returned to normal nightly baseline before bedtime.
Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.
Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.
Psilocybin calmed my body and mind. Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.
Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.
My cortisol and DHEA-S dropped by 42% and 45%, respectively, suggesting a profound inhibition of the Hypothalamus-Pituitary-Adrenal (HPA) axis, which corresponds with the "after-glow" effect.
This data confirms: + I had a normal adrenal reaction to psilocybin + a fast system reset (healthy HPA function)+ + no prolonged stress response
Psilocybin produced a large, expected cortisol rise at peak effect. Clinical studies show a 100-300% surge in cortisol between 90-120 min after dosing.