Macrodosing psychedelics with a trained professional is more effective for triggering directed rewiring plasticity than microdosing.

“He said, "Macrodose." And I thought, okay, I'm not a guy who, you know, I'm not into, I'm not, I'm not a pushing this. I'm not a proponent. I said, "You're kidding me. Why? Why would you say this?" This guy runs an NIH funded lab at Johns Hopkins School of Medicine. I thought, "Why?" And he said, "Because the one session with a trained professional that's triggering rewiring plasticity, that's guided, is," as far as they know from the data, you can go back and listen to, these are his words, not mine, but he's the expert in this area, "are encouraging plasticity in a particular direction."”