Therapeutic effects of drugs like ketamine, psilocybin, and MDMA may involve multiple neurobiological processes with different time courses.

“the experience that one has subjectively while they are under the influence of a drug like ketamine or psilocybin or MDMA sets off a series and in fact multiple serieses is that a word multiple types of processes in the brain some of which rely on things like nmda receptor bdnf Etc type neuroplasticity others which rely on the opioid receptor pathway and that each of these have different time courses such that some provide immediate relief in the days and hours after treatment some in the weeks after treatment and some more durable long- lasting changes that can occur over months or maybe even years”