Andrew Huberman· PhD
LSD and psilocybin, as I understand trigger activation of particular serotonin receptor mechanisms, may or may not lead to more widespread activation of the brain that one wouldn't see otherwise.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
LSD and psilocybin, as I understand trigger activation of particular serotonin receptor mechanisms, may or may not lead to more widespread activation of the brain that one wouldn't see otherwise.
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psilocybin is serotonin if you look at the structure of psilocybin and it looks like serotonin so we're talking about is a massive dose of Serotonin and psilocybin appears to bind near selectively to a particular serotonin receptor and the outcome seems to be enhanced or more more broad connectivity between brain areas that normally are not communicating with one another
LSD and psilocybin, as I understand, trigger activation of particular serotonin receptor mechanisms may or may not lead to more widespread activation of the brain, more that one wouldn't see otherwise.
And as you mentioned, psilocybin is a serotonergic agonist. So it activates, as far as I know, the 5-HT2A receptors and maybe others as well which obviously, serotonin is a pharmacological target of many different antidepressants.