The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
First of all, it's a very high-quality paper carried out in the laboratory of Robin Carhart-Harris at UCSF... they looked at the connectivity between those brain areas in those same individuals when they were not under the influence of these drugs and found more extensive connectivity. All of which pointed to an enhanced lateral connectivity, less hierarchical organization effectively more interconnection and communication between different brain areas.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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psilocybin expands the functional connectivity of the brain while one is under the influence of psilocybin. And it does seem that some of that expanded functional connectivity persists after the effects of psilocybin have worn off.
And when it comes to psilocybin, the serotonin increase is what effectively causes broader connectivity in the brain. And what's interesting is that both of those drugs increase plasticity mainly through increases in serotonin but working on very different receptors. So they have different types and outputs of plasticity.
and nowadays there's a lot of at least interest if not enthusiasm more work is needed on um the very psychedelics in particular psilocybin and MDMA um for depression and PTSD um more specifically and while those are more in the serotonergic pathway the my read of the data is that you know they they're creating you know more brainwide connectivity at resting state