The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
But among the most important results I can summarize from the discussion and here I'm paraphrasing, that the change in baseline levels of depression that is at week three following the psilocybin session was significantly better. That is people experienced more relief or more people experienced more relief from the 25 milligram dose than from the 1 milligram dose.
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The important point is that a single dose of 25 milligrams of psilocybin provided significant relief from treatment resistant depression in this particular patient population. ... And that is summarized nicely in figure 2 of the paper. Because they explored these people's levels of depression out to week 12. And they still saw a significant degree of depression relief 12 weeks after the single 25-milligram psilocybin dose session.
This really points to the fact that the 25 to 30 milligram dose that's used in the largest numbers of studies exploring treatment resistant depression really seems to be, I don't want to say the best dose, but the most effective dose at least in this clinical context, in this set and setting and with this particular patient population.
So what this study found is that one of the key features, if not, the key feature of a positive quote-unquote
A group from the UK published this summer uncontrolled pilot study in, I think, it was 15 volunteers with treatment-resistant depression in which they gave psilocybin. And they showed large effects and sustained effects out to at least a couple of months.