The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So microdosing is the aim of taking against something around a 10th of what would be sort of an entry-level psychedelic dose for whatever compound. So like, yeah, with psilocybin, usually people, almost never do people have like pure psilocybin. One milligram of psilocybin would be in the range of a microdose. More likely, people are going to have mushrooms, so something like a half of a gram of mushroom, a quarter gram.
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So 1 gram of mushrooms being 1000 milligrams means that it contains approximately. And, again, it's approximately 10 milligrams of psilocybin.
And the typical dosage that's used in clinical studies ranges from 1 milligram often given repeatedly from day-to-day over long periods of time, so-called microdosing. And really that 1 milligram per day or even up to 3 milligrams per day repeatedly over time is what people generally think of as microdosing.
And typically, the dosages used in these trials are 25 milligrams of psilocybin. And we talk about one recent trial, in particular, that compared 25 to 10 milligrams to more frequent use of very small amounts. 1 milligram over 3 weeks, for instance.