Understanding the serotonin 2A receptor is crucial for discussing psilocybin's effects, dosing, and spacing.

“And so in order to understand how psilocybin works and in order to understand proper dosing profiles and spacing of sessions a.k.a. journeys, we really need to talk a little bit more about the serotonin to a receptor, where it is in the brain, what sorts of things happen when psilocybin binds the serotonin to a receptor, and how those things set in motion, the various changes, the neuroplasticity that allows people to feel better in terms of their mood, and as you'll soon learn, can experience more pleasure and joy from things like music and enhanced creativity.”