Psilocybin's relief for depression involves binding to a serotonin-like receptor, inducing brain-wide changes that alter self-reflection and mood stably over time.

“it was a pretty straightforward model psilocybin looks a lot like serotonin chemically except that psilocybin binds a particular receptor when that receptor is bound it allows these brainwide changes those brainwide changes seem to change one's reflection on oneself so-call ego dissolution changes in mood that are stable over time etc etc”