Andrew Huberman· PhD
So this is neuroplasticity as the consequence of one first time session with 25 milligrams of psilocybin.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So this is neuroplasticity as the consequence of one first time session with 25 milligrams of psilocybin.
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This decrease in axial diffusivity translates to a higher fidelity of communication between the prefrontal cortex and the thalamus and striatum as opposed to less.
And the MRI, seeing deep into the brain was probably our most exciting result where we didn't just see some functional brain changes, but we've seen some anatomical brain changes as well. And we used a technique called diffusion tensor imaging that looks at the cabling of the brain, the white matter tracts. And we saw a change in major tracts. So we limited our search space to really thick tracts. Really thick fibers. And the fibers that came through as changing were ones that traveled between the prefrontal cortex and the thalamus and the striatum. There were two tracks, two prefrontal tracks that changed. And they changed in the direction of a decrease in axial diffusivity, which could be interpreted as tract integrity where a decrease would be an increase in tract integrity.