The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In a remarkable study involving long-term smokers, a combination of two to three psilocybin sessions with cognitive-behavioral therapy resulted in an astonishing 80% confirmed abstinence rate at 6 months. This quit rate far surpasses those typically seen in conventional smoking-cessation treatments, which often achieve 20–35% at 6 months.
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One large psilocybin dose beat nicotine patches by 6x odds for smoking cessation.
Nicotine patch: 10% prolonged abstinence Psilocybin: 40.5% prolonged abstinence
And remarkably, we had 80% abstinence rates at 6 months which in the smoking world is just completely unheard of.