Psilocybin journeys can invoke neuroplasticity by activating brain networks more broadly, leading to abnormal thinking and perceiving.

“Rather it seems that the increase in connectivity is leading provided set and setting are correct, provided safety protocols are followed to positive rewiring or adaptive rewiring of neural tissue.”

“And in that way, it's remarkable, if you think about it, that everyone has different lives different experiences. Psychedelics, in this case, psilocybin are activating these brain networks that each of us has more broadly than they would normally be activated. These are very abnormal patterns of thinking, and perceiving, and experiencing our emotional and physical life, et cetera.”

“In fact, many people don't realize this. But much of the positive changes that are possible with proper-- and I do want to underscore proper psilocybin therapeutic approaches, takes place after the session in which one feels all typical or typically associated effects of psilocybin like hallucinations and changes in thought patterns, et cetera.”

“But there is now what I would refer to as a center of mass of data that point to the fact that psilocybin when taken in the appropriate set and setting, at the appropriate dosages can invoke the sorts of neuroplasticity and changes in emotionality, in perceptual experience, not just during the psychedelic session, but for long periods of time after the psychedelic session.”