Psilocybin and escitalopram (Lexapro) treat depression through different mechanisms.

“we came to the conclusion that psychedelics treat depression in a different way to antidepressants and the papers published in journal psychopharmacology it's called a tale of two receptors it's a free download uh feel free to read it because it conceptualizes that there are two ways you can lift depression one way is with it with with lexapro or other similar drugs that enhance serotonin in the limbic system and there they basically block the stress response and we know that stress is a major cause of depression you block stress induce depressive changes in that system and that allows the limbic system to recover so that it's a bit like if you have a broken leg you set the leg in plaster so that the bone can heal itself ssris set the limbic system in plaster so over a period of six to eight weeks they can heal and get you over your depression and that's through a particular subtype of serotonin receptors called the serotonin 1a receptor which is in the very expressed in the limbic system but we think psychedelics we know psychedelics work in the cortex and they disrupt cortical processing and disrupt we think the deep persistent ruminations and negative thoughts of depression”

“and that's through a particular subtype of serotonin receptors called the serotonin 1a receptor which is in the very expressed in the limbic system but we think psychedelics we know psychedelics work in the cortex and they disrupt cortical processing and disrupt we think the deep persistent ruminations the negative thoughts of depression”