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Psilocybin & Depression: A Discussion on David Nutt's Recent Study — Whalespan

Content›Video›Psilocybin & Depression: A D…

Psilocybin & Depression: A Discussion on David Nutt's Recent Study

Peter Attia10m · 2021-11-03

Claims Made

14

Claims Supported

4

Support Rate

29%

Support rate

4 of 14 claims supported

4 supported10 partial / not

Claims from this content

12

◐Partially SupportedA clinical trial compared 25mg psilocybin, 10mg psilocybin, and escitalopram over 3 weeks.◐Partially SupportedA psilocybin therapy versus escitalopram trial used escitalopram for six weeks and a very low dose of psilocybin.◐Partially SupportedPsilocybin and escitalopram (Lexapro) treat depression through different mechanisms.✓Well SupportedSSRIs and psilocybin are both tools for plasticity that drive serotonin.◐Partially Supported

More from Peter Attia

Peter Attia on Zone 2 Cardio

Peter Attia on Rapamycin (with Matt Kaeberlein)

Attia walks back the clinic protocol: too aggressive for healthy adults

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Psilocybin performed well on measures of well-being in a study comparing it to escitalopram for depression.

◐Partially SupportedPsilocybin, at a dose of 25mg, may offer similar antidepressant benefits to Lexapro without the sexual side effects and blunting of pleasure.

◐Partially SupportedSSRIs like Lexapro can dampen sexual activity by reducing limbic system activity and may blunt overall enjoyment of life.

◐Partially SupportedA study comparing psilocybin and escitalopram found psilocybin performed better on well-being measures, but the primary outcome was not met.

◐Partially SupportedEscitalopram (Lexapro) doses of 10mg or 20mg can increase efficacy but also side effects like sexual dysfunction.

◐Partially SupportedA significant number of patients cannot tolerate SSRIs despite receiving anti-depressive or anti-anxiolytic benefits.

◐Partially SupportedA study in the New England Journal of Medicine suggests psilocybin has efficacy comparable to escitalopram.

✕Not SupportedSSRIs like escitalopram can cause sexual side effects and dampen libido, potentially trading depression relief for sexual dysfunction.