A psilocybin therapy versus escitalopram trial used escitalopram for six weeks and a very low dose of psilocybin.

“the reality was the truth was it wasn't it wasn't powered for non-inferiority if you want a proper non-inferiority study in psychiatry takes a hundred and fifty patients in each arm we could never afford to do that there's very few that we've ever been done except by what probably none have been done except by companies we could not statistically do a non-inferiority study so we had to just do a kind of comparison”

“the new england journal so the reality was the truth was it wasn't it wasn't powered for non-inferiority if you want a proper non-inferiority study in psychiatry takes 150 patients in each arm we could never afford to do that there's very few that have ever been done except by com well probably none have been done except by companies we could not statistically do a non-inferiority study so we had to just do a kind of comparison and and the answer was that well we we had to pre we you know use pre-specify we've pre-specified two outcomes the quids and the well-being and it did brilliantly on the well-being but because that's kind of not well that's sort of soft wishy-washy psychiatry we they insisted that we use the quids as the primary”

“it wasn't powered for non-inferiority if you want a proper non-inferiority study in psychiatry takes 150 patients in each arm we could never afford to do that”