Andrew Huberman· PhD
You were involved in a clinical trial that was published last year comparing 25 milligrams of psilocybin to 10 milligrams of psilocybin to a drug called escitalopram.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
You were involved in a clinical trial that was published last year comparing 25 milligrams of psilocybin to 10 milligrams of psilocybin to a drug called escitalopram.
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and in the end on the the primary measure there was no difference that cytosine at six weeks was as good uh as um or equal to as uh escitalopram on that particular measure which was a a particular self-report measure called the quid self-report which has been used quite extensively in research in the states particularly in the star d study
but you couldn't just say hey you're on lexapro here you're on side of simone we had to blind it and that's quite difficult with psychedelics so the way we got we did that was to tell everyone they were going to get cytoscybin but half the group got a low dose a placebo dose of one milligram dose and have got a high dose of 25 milligram dose but they all went through the same psychotherapy depending it didn't matter what dose they got they all got all the same preparation and the psychotherapy that goes with a high dose of cytosimin
and then they all got pills but the acetalopram group got escottarapram and the um cytosine group got placebo so they're both getting two pills one is getting that's a placebo plus the high dose of psilocybin the other okay and the point of that is what's called critical equipoise people have to believe that they're getting the best they can
the way we got we did that was to tell everyone they were going to get cytocybin but half the group got a low dose a placebo dose of one milligram dose and a half got a high dose of 25 milligram dose but they all went through the same psychotherapy depending it didn't matter what dose they got they all got all the same preparation and the psychotherapy that goes with a high dose of cytosimin and then they all got pills but the escitalopram group got estee tarabram and the the cytocybin group got placebo