Ketamine and psilocybin rewire circuitry and impact layer five neurons, leading to neuroplasticity and dissociation from negative moods.

“So you'll hear more about microdosing and other psychedelics and their impact on depressive states and major depression in the episode with Matt. But for the time being, it really seems as if, again, we're looking at neuroplasticity, we're coming back to layer five, just like with ketamine and PCP. We're hearing about layer five, we're hearing about rewiring of circuitry, we're hearing about a dissociation or a distancing of oneself from these negative moods and affects and narratives”