David Sinclair· PhD
I take 500 mg quercetin, a suspected senolytic and a SIRT1 activator.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I take 500 mg quercetin, a suspected senolytic and a SIRT1 activator.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Often ignored by the senolytic field is the fact that quercetin activates SIRT1, a longevity/survival enzyme and this could also help explain the results (see Howitz et al Nature 2003)