David Sinclair· PhD
He showed, for instance, that it only takes a quick course of two senolytic molecules—quercetin and dasatinib—to eliminate the senescent cells in lab mice.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
He showed, for instance, that it only takes a quick course of two senolytic molecules—quercetin and dasatinib—to eliminate the senescent cells in lab mice.
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When he did this, he extended their lifespan by 36 percent!
That was discovered first as a senolytic by Jim Kirkland at the Mayo Clinic who combined it with a drug called dasatinib and together those two molecules are potent killers of senescent cells. And those have been put into mice and into humans where they are showing really remarkable effects in treating age-related diseases.
Very early clinical evidence suggests quercetin in conjunction with dasatinib can clear out age-related senescent cells in some tissues.