Peter Attia· MD
how much rapamycin gets in the brain. Are you actually affecting the brain? You know, I don't think those are open questions to some extent.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
how much rapamycin gets in the brain. Are you actually affecting the brain? You know, I don't think those are open questions to some extent.
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
I think here this is not as relevant because I think it's a very very lipophilic molecule I see so it's more about it's it's more about the solubility than it is yeah I think um you you almost sort of need to I I almost see like a lot of it get trapped in the membrane you almost sort of need to sort of push it uh through and you know the brain has a lot of things like myelin which are all very lipop so I think that I think there's almost like a the way I always saw it was a bit of a sink of of trapping Rapa in places that maybe it's not so effective
there's disagreements out there about how effectively does Romy cross the blood brain barrier how how much rapamycin do you need to get inhibition of M torque 1 in the brain
I speculate that that's probably true with rapamycin and so in the context of Aging it wouldn't surprise me if you actually get better penetration of Romy across the bloodb brain barrier um in aged animals and and in aged people potentially
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.