David Sinclair· PhD
The reason is that it's extended the life span of every organism it's been given to in low doses, not immune suppressing doses.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The reason is that it's extended the life span of every organism it's been given to in low doses, not immune suppressing doses.
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
it's the only drug that's uniformly extended life across a billion years of evolution
it is the most robust and reproducible drug at least from preclinical studies that we know about today for impacting not only longevity but to the extent that we can measure various metrics of Health span um in complex animals
Rap ayon also seems to positively impact pretty much every aspect of Health span that we measure
Romy for a small molecule is probably the only pharmacological intervention that has been uh reproducibly shown to robustly increase lifespan and health span across that broad evolutionary Spectrum
So I I still think rapamy is the gold standard for a small molecule impacting aging. At the end of the day, it may not be the best, but right now I think the evidence is still the best.
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.