Peter Attia· MD
what seems to be the case both in mice and people is that short-term treatment with rapamycin in an old mouse or an old person followed by a two-week washout where they stopped taking the drug when you then test immune function at least as measured by a vaccine response you get a better response so one model would be that the treatment with rapamycin is restoring immune function in an aged animal probably through enhanced stem cell function although I don't I think that that hasn't really been demonstrated clearly and you might need that washout here if there is an immunosuppressive effect you might need that washout period to be able to see that rejuvenation and immune function again that's really speculative though cuz nobody's done in Jones paper did they do I'm sure they didn't actually know what I think about it they didn't have enough people in this study we've been very interesting to have seen the immune challenge without the washout subset no I was just gonna say nobody's done it and either mice or in people that actually would be a fairly easy experiment to do in mice the problem is you would never get an NIH study section to fund that experiment because we already kind of know the answer that it rapamycin works they wouldn't be viewed as an even though it's really important from a translational perspective it wouldn't be viewed as innovative or important enough for somebody to fund a grant to do it so it's it's an unknown and I don't know how long it'll be till we actually get the answer to that question