Peter Attia· MD
everolimus does the same thing it also binds to fkbp
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
everolimus does the same thing it also binds to fkbp
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
the next drug yeah sorry semantics aside yeah after yeah yeah after rap immune rapamycin serolamis we're talking about the experiment that we're about to discuss in detail is using a different molecule it's using a different molecule we called it rad001 in the paper the generic name is everolimus it was the second one
rapamycin binds to all of them in a few specific cases that's been shown to be true
you know there are these classes of what people call rapalogs which are all going to be chemical derivatives of Ramy but biochemically they work by a pretty similar mechanism they all bind fkbp12 and then it's that complex that inhibits mtor complex one
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.