Rapamycin is not stable at the gastric pH of mice, and the same appears to be true in humans.

“the reason why they had to make this e-wrapa is because rapamycin isn't stable at the gastric ph of mice same thing seems to be true in people”

“i think what they didn't recognize was that it was going to take 18 months or so to figure this out so once they finally developed this in what they call e-wrap encapsulated rapamycin it it's basically designed so that it won't break down in the gastric ph”

“and randy strong who's one of the the pis on the itp — who's also got a strong biochemistry background i think recognized pretty quickly that the rapamycin wasn't stable in the food we could actually come back to this if you want to because this is relevant for for people as well so and it gets broken down in the ph of the the gut right so so basically if they just put the powder in the food there's no bioavailability it doesn't get taken up by the mice”

“the famous One the early one was rap ayon about 90% of the rap ayin that was given to mice in the food never made it into the mouth because it's digested in the stomach and the acid conditions of the stomach it gets degraded and so Randy with colleagues of his uh worked out a way to encapsulate the Romy in a capsule plastic capsule that makes it through the stomach and dissolves in the more alkaline conditions of the small intestine”