Peter Attia· MD
I think you're probably right that at least part of the story is that one of the steps in the progression to cancer is evolving to ignore or that signal to break yeah turning down mTOR so rapamycin may not be effective there
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I think you're probably right that at least part of the story is that one of the steps in the progression to cancer is evolving to ignore or that signal to break yeah turning down mTOR so rapamycin may not be effective there
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
and it's because the cancers evolve to bypass the mtor break or to bypass the ability of Rapa to inhibit mtor so that's a case where the intervention that's a really good point that we all take for granted that I think is worth noting rapamycin can be unsuccessful as a chemotherapeutic agent and can yet be very successful as a cancer preventive agent absolutely
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.