Peter Attia· MD
so there are now multiple different places in the body at least in mice where you actually see functional improvements back to a more youthful state
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so there are now multiple different places in the body at least in mice where you actually see functional improvements back to a more youthful state
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
we've recently published that alveolar bone levels so in the mouth the brown around the teeth can be rejuvenated back to a more youthful level by short-term treatment with rapamycin
so there are now multiple different places in the body at least in mice where you actually see functional improvements back to a more youthful state and so I don't think rapamycin is gonna do that for everything but at least four tissues and organs where stem cell senescence plays a big role I suspect that rapamycin can have not just an effect on delaying declines but actually bring things partially back towards a more youthful functional state
in pretty much every tissue where this has been looked at you take an old mouse you give it rapamycin functionally it's younger in that tissue or that organ and lifespan is extended
at least all of the data that i've seen limited in people extensive and mice uh eight weeks is enough to give you essentially that full benefit for whatever the functional output is that you're looking at maybe not for lifespan
I also think that's how you can sort of account for the persistent effects that we see with rap ayon treatment transiently in mice in other places like the heart or the brain or the ovaries or the oral cavity where we know that 6 to 12 weeks of treatment is enough to apparently functionally rejuvenate those tissues and organs and that that effect persists for some period of time going forward after you stop the treatment
where you can actually see structural Rejuvenation of the ovaries from a uh atrophied state to a to a you know what at least at a morphological level appears like true rejuven of the actual or the the ovary wow
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.