Peter Attia· MD
So there's a there's a study going on at at uh Cornell or Columbia um that's looking at the use of rapamy to extend fertility in women.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
So there's a there's a study going on at at uh Cornell or Columbia um that's looking at the use of rapamy to extend fertility in women.
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
So, um, rapamy, as some of your listeners may know, is kind of used in other sort of anti-aging type context. So the there's some animal data that shows that maybe rapamy might extend fertility in that remember this the egg cell death that we talked about earlier by like preventing that to some degree so that the eggs last longer and you're fertile for for more years.
So if it's uh slowing the aging process of the human, is there a chance it's slowing the aging process of the egg?
RAPA is being investigated as a potential drug to extend the fertility years in a woman.
RAPA is being investigated as a potential drug to extend the fertility years in a woman.
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.