David Sinclair· PhD
It's solubility in fat would explain why we saw better effects of resveratrol on the health and lifespans of mice eating a fatty diet than a standard diet
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It's solubility in fat would explain why we saw better effects of resveratrol on the health and lifespans of mice eating a fatty diet than a standard diet
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other indices of maximum lifespan the resveratrol was not a benefit and when you look at the lifespan effects in the mice that were not on this toxic diet there weren't any so paper in nature which was widely misinterpreted over interpreted as a demonstration of a drug that slowed aging was a drug that did not extend maximum lifespan except in mice that were dying of this extremely unusual lipid-specific poisoning
He did the study with us on the mouse, resveratrol study that showed that on a high-fat diet, those mice were extremely healthy and longer lived and their organs, when they opened up the mice, they were pristine.