The doses of resveratrol used in early mouse studies were megadoses.

“the equivalent of barrels of grape exactly like doses so high you could there you know if you recall we're both of an age that's old enough to remember this there was this period of time when people thought this was the explanation to the French paradox right why on average do the French live longer when they consume so much wine and the answer was it's got to be the ratol turns out that's not true at all because yeah you would need to be drinking your body weight and wine a day to get the doses of RIS veratrol that were needed to produce this effect”