Resveratrol administration to mice on a high-fat diet extended their lifespan by approximately 20% while they remained obese.

“In the original @Nature paper where we fed resveratrol to mice on a high fat diet, the mice lived about 20% longer but were still obese.”

“Twenty years ago, SIRT1 was shown to be directly activated by resveratrol, a chemical found in red wine that extends lifespan in model organisms...”

“There have been a number of animal studies on resveratrol going back almost 20 years. Now we're seeing extended replicative lifespan in yeast. We're seeing activation of AMPK in rodents. What are these things telling you? - Well, they're similar to what we expected from the sirtuins. They defend the body. They raise the metabolic rate. They protect against free radicals. And when we see research given to these rodents, what the biggest surprise was was that they were protected against a high-fat so-called Western diet. Those mice on resveratrol, even though they were really obese on this really chunky meal, they lived as long as the lean mice that we had as the control group.”

“And that was really, as far as I know, the first study of any that showed that you could mimic caloric restriction with a molecule and be fat but live as healthy as a lean animal.”

“but does it extend the lifespan of a mouse that's eating a Western diet absolutely it does that's been done many times”