David Sinclair· PhD
This is a relatively low dose, Doses in mice have ranged from 20-400mg/kg/d In humans, this would translate to about 150 mg for 70 kg person
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
This is a relatively low dose, Doses in mice have ranged from 20-400mg/kg/d In humans, this would translate to about 150 mg for 70 kg person
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
It's not a one-to-one, it's not like you should take 3000 times as much as the mouse had. If you were 3000 times bigger than the mouse is. Right, it's not just proportional. It's actually more related to our surface area and how much the drug can get into our bodies versus the mouse and the calculation for a mouse, which is called the allometric scaling, is about 12. So you multiply it, let's say, if the mouse has 100 milligrams, 1.2 grams for a human. For a rat it's 3, for a mini pig it's 1 to 1. Turns out we have about the same surface area as a mini pig.