We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
Methylene blue is an MAOA, a monoamine oxidase A inhibitor. It's a strong one. This means it can cause serotonin syndrome if you're taking anti-depressants or other compounds that increase serotonin in your body like 5HTP, rodeiola, Sam, or St. John's Ward.
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So it's really important to understand that when you take methylene blue you are affecting serotonin metabolism in your brain and in your body. By inhibiting MAOA in a significant way, you are increasing the amount of serotonin, a neurotransmitter in the synaptic cleft between the neurons because that's where it gets broken down by these monoamine oxidase enzymes. We'll come back to why that's so important later in this video, but for now, it's very important to understand this because if you're taking anything already that is going to increase your serotonin, you're at an increased risk of serotonin syndrome.