Paul Saladino· MD
my concerns about rice are generally the metals and the soil and how much accumulates in it and stuff and so i'd be curious wild rice wild what an aquatic grain you go out by canoe this is a wild born grain you go up by canoe two people and and you knock this rice into the boat and you process that into the most incredible fully wild non-agricultural food so anyway i just want to clarify this is not like patty grown stuff i'm talking about i'm talking about a foraged wild food interesting yeah yeah i'm interested in and i i want it just be so interesting to get a time machine we're going to build one be like you know at what point did they start doing this you know um and what were the other pressures around um i think i i agree with you i think sucrose has been a part of the human diet forever uh certainly honey is eaten everywhere in the world where it is found and i'm sure that people ate maple syrup where you are evolutionarily and then in terms of the drugs quote unquote i think that it kind of goes back to the plants as medicine versus plants as food yeah and yes i think that um psilocybin super valuable compound i've used psilocybin twice i've talked openly about this in on multiple you know occasions and it's been very valuable for me it's been very insightful i've never used dmt or done ayahuasca though it's something that i intend to do in the future um but you know even even within mainstream medicine now um mdma though that's not necessarily from a plant but psilocybin certainly is becoming more mainstream and is used in a lot of psychedelic assisted psychotherapy and i think it will gain acceptance and uh fda approval in the future for things like ptsd so that's a very valuable molecule you're publicly trading companies now who are in that game which is interesting to see yeah yeah yeah and we don't we probably shouldn't use psilocybin every day like it's not a food right this is and that would be an interesting conversation that i could have with them because there is certainly tachyphylaxis with these compounds and by that that's a technical term that i will clarify means like the body does adjust you know if you give the body metoprolol or a beta blocker if you give the body a pharmaceutical molecule from a plant generally uh one of these compounds the body will adjust we see this with caffeine right it's an adenosine receptor antagonist and the body certainly changes the way it does things with cyclic amp and that's why people get withdrawal when they stop it so there is a tachyphylaxis effect and with some of these compounds i worry about overuse and i worry about long-term over-use of psilocybin i certainly think we wouldn't want a long-term overused dmt but ritualistically yeah these things i believe have value even nicotine is used by people uh you know whether they're you know smoking tobacco or chewing tobacco or something evolutionary i mean people do all kind of snuffing it oh yeah absolutely you know i paint uh uh yeah all these things like they're uh they're used and i but i think you know long term they're going to change our physiology so i think that it's my sense not living an indigenous tribe is that they're regarded more as sacramental things rather than consistent all the time um or maybe that's the maybe that's not the way that that hasn't been what i've seen yeah again i mean i'm no anthropologist but boy it seems like wherever these things are found like you brought up caffeine so that whole group of xanthines so you know theobromine theophylline caffeine wherever they are found they are like or you know there's that thing people will say that trope like well the native americans i mean whenever you hear that you know like we're in for some you know like well the native americans like 500 nations dude like they're not all doing the same thing but people say the native americans use tobacco ritualistically it's like yeah how many times a day they have a ritual because they're you know it's a highly addictive thing so you know coca it's like they're chewing it every night in the jungle you know happy they're all the time up the nose you know you see this use that you're like wow that's i mean i wouldn't you know what i mean so it does seem like you know is that just the nature of human addiction or is there value there do i am i putting hunter-gatherer groups on too