Genetic predispositions may be triggered by external factors, potentially leading to adverse health outcomes.

“So I like that general concept that we're and in some cases maybe that's beneficial. I'm not saying getting ALS is beneficial, but maybe we're attuned certain ways because in ancient times we had to deal with things like TB and stuff and the idea that you would be well the classic is cickle cell, right? That folks with cickle cell mutations might be more resistance to malaria. So so maybe some of this tuning helps you in some ways but is adverse in other ways or more makes you more susceptible. Let's put it that way.”