Peter Attia· MD
on all these levels anabolic resistance can reside so it's impossible to find it
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on all these levels anabolic resistance can reside so it's impossible to find it
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the term anabolic resistance is is intuitive because obviously people understand what insulin resistance is but with insulin resistance we we can actually really explain mechanistically what's happening I referred to Jerry Schulman he provided a very very uh elegant explanation of what's happening intracellularly right what the tri what the triglyceride or diog glyceride if I'm not mistaken is doing in the cell and how it's impeding the signal transduction to move the glute for transporter up to the translocated site to bring more glucose in ETC I haven't followed that description but I mean it's still as as I know as I believe it's still a discussion which fatty acid intermediate is actually causing the whole signaling is it the storage of the fat is the inflammation that you get from the storage of fat is it diil glycerol is it are the ceramides the fatti ailoa I mean yes but it's at least the inability to process that fat in the muscle is inducing insulin resistance so the question now is do we have the same level of detail around what is actually inducing anabolic resistance which is a topic that I don't think people are as familiar with but un fortunately need to be as familiar with given its prevalence under two conditions inactivity and aging I think that's that's that's the the million dooll question
as we get older um the muscles become less sensitive to the effects of the amino acids you know I won't cover it here because I covered it in Great depth with on the podcast recently with Luke von Lon um but but it was actually the first time I had a really good explanation at least speculation as to why anabolic resistance is taking place
so that's how he coined anabolic resistance and that was I think 2005
Anabolic resistance. So, so our when we eat protein, right, we we're breaking down amino acids and you know the primary amino acid that is that is anabolic is leucine, right? So these amino acids like leucine are getting into the muscle tissue and that is instigating it's a signal to increase muscle protein synthesis, right?